Our research outputs are evidenced by over 140 peer-reviewed publications, reviews, and other published contributions in the international literature.

The full list of publications can be viewed here.

Selected Articles:

A Sustainable and Scalable Multicomponent Continuous Flow Process to Access Fused Imidazoheterocycle Pharmacophores. B. J. M. Baker, W. J. Kerr, D. M. Lindsay, V. K. Patel, and D. L. Poole, Green Chemistry, 2021, 23, 280-287.

ACS Catalysis

Computationally-Guided Development of a Chelated NHC-P Iridium(I) Complex for the Directed Hydrogen Isotope Exchange of Aryl Sulfones. W. J. Kerr, G. J. Knox, M. Reid, T. Tuttle, J. Bergare, and R. A. Bragg, ACS Catal., 2020, 10, 11120-11126.

View Table of Contents for Cobalt Catalysis in Organic Synthesis

Recent Advances in the Pauson-Khand Reaction. D. M. Lindsay and W. J. Kerr, Cobalt Catalysis in Organic Synthesis: Methods and Reactions, 1st Ed. M. Hapke and G. Hilt (eds.). Weinheim, Germany, 2020, Chapter 8, pp 259-285.

Structure-based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-terminal Bromodomains that Retains an Anti-inflammatory and Anti-proliferative Phenotype. C. R. Wellaway, P. Bamborough, S. G. Bernard, C.-w. Chung, P. D. Craggs, L. Cutler, E. H. Demont, J. P. Evans, L. Gordon, B. Karamshi, A. J. Lewis, M. J. Lindon, D. J. Mitchell, I. Rioja, P. E. Soden, S. Taylor, R. J. Watson, R. Willis, J. M. Woolven, B. S. Wyspiańska, W. J. Kerr, and R. K. Prinjha, J. Med. Chem., 2020, 63, 9020-9044.

Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 integrin inhibitor – (3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2- (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation. T. N. Barrett, J. A. Taylor, D. Barker, P. A. Procopiou, J. D. F. Thompson, J. Barrett, J. Le, S. M. Lynn, P. Pogany, C. Pratley, J. M. Pritchard, J. A. Roper, J. E. Rowedder, R. J. Slack, G. Vitulli, S. J. F. Macdonald, and W. J. Kerr, J. Med. Chem., 2019, 62, 7543-7556.

PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase is Inhibited by Covalent Binding. C. P. Tinworth, H. Lithgow, L. Dittus, Z. I. Bassi, S. E. Hughes, M. Muelbaier, H. Dai, I. E. D. Smith, W. J. Kerr, G. A. Burley, M. Bantscheff, and J. D. Harling. ACS Chem. Biol., 201914, 342-347.

Iridium-catalyzed Csp3-H Activation for Mild and Selective Hydrogen Isotope Exchange. W. J. Kerr, R. J. Mudd, M. Reid, J. Atzrodt, and V. Derdau, ACS Catal., 2018, 8, 10895−10900.

Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences. J. Atzrodt, V. Derdau, W. J. Kerr, and M. Reid, Angew. Chem. Int. Ed., 2018, 57, 1758-1784.

C–H Functionalization for Hydrogen Isotope Exchange. J. Atzrodt, V. Derdau, W. J. Kerr, and M. Reid, Angew. Chem. Int. Ed., 2018, 57, 3022-3047.

Cover image

A Practical and General Amidation Method from Isocyanates Enabled by Flow Technology. J. D. Williams, W. J. Kerr, S. G. Leach, and D. M. Lindsay, Angew. Chem. Int. Ed., 2018, 57, 12126-12130.

Go to journal home page - Tetrahedron

Total Synthesis 2-epi-a-cedren-3-one via a Cobalt-catalysed Pauson-Khand Reaction. W. J. Kerr, M. McLaughlin, L. C. Paterson, and C. M. Pearson, Tetrahedron, 2018, 74, 5062-5068.

Go to ACS Catalysis

Site-selective Deuteration of N-Heterocycles via Iridium-Catalyzed Hydrogen Isotope Exchange. W. J. Kerr, D. M. Lindsay, P. K. Owens, M. Reid, T. Tuttle, and S. Campos, ACS Catal., 2017, 7, 7182-7186.

Iridium-catalyzed Formyl-selective Deuteration of Aldehydes. W. J. Kerr, M. Reid, and T. Tuttle, Angew. Chem. Int. Ed., 2017, 56, 7808-7812.

Iridium-catalysed ortho-H/D and -H/T Exchange under Basic Conditions: C-H Activation of Unprotected Tetrazoles. W. J. Kerr, D. M. Lindsay, M. Reid, J. Atzrodt, V. Derdau, P. Rojahn, and R. Weck, Chem. Commun., 2016, 52, 6669-6672.

Iridium(I) NHC/Phosphine Catalysts for Mild and Chemoselective Hydrogenation Processes. W. J. Kerr, R. J. Mudd, and J. A. Brown, Chem. Eur. J., 2016, 22, 4738-4742.

%d bloggers like this: